An in vitro assessment of inhibitory effect of 16 strains of probiotics on the germination of Candida albicans


Huan Tang, Jiong Ren , Jing Yuan , Benhua Zeng and Hong Wei*

The purpose of the study was to evaluate the antagonistic activity of probiotics isolated from products to germination of Candida albicans in vitro. The spent culture supernatant, live bacteria, heat-killed bacteria of 16 strains of probiotics and main bacterial short-chain fatty acids were applied to inhibit the germination of C. albicans in vitro by crystal violet-based germ tube assay. Neutral SCS of all the probiotcis evaluated in this research could decrease germination significantly and live bacteria of Lactobacillus rhamnosus LGG, Lactobacillus plantarum LA, Lactobacillus johnsonii JCM1022, Bacillus Longum-2, Bacillus sub. and Bacillus lich could partially inhibit the conversion of yeast to germ. However, all the heat-killed bacteria failed to control the germ tube formation. Furthermore, only butyric acid blocked the conversion of yeast to hypha among all the SCFAs. These results suggest that L. rhamnosus LGG, L. plantarum LA and L. johnsonii JCM1022, B.Longum-2, Bacillus sub. and B. lich maybe potential strains to use as antifungal drugs and the inhibition seems to have direct correlation to the metabolites butyric acid

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