Toxicological renal effects of Bridelia ferrugineatreated wastewater in rats.


Kolawole O. M.1, Olayode J. A.2, Oyewo O. O.2, Adegboye A. A1and Kolawole C. F.2

The effect of wastewater fed to rats following treatment with a 2.5% (w/v) methanolic crude extract of Bridelia ferruginea for different times (0 to 96 h) was investigated. Kidneys of rats fed with the treated wastewater was subjected to histological examination and compared to negative (rats given wastewater treated with methanol alone), positive (rats given untreated wastewater alone) and standard (rats given sterile distilled water alone) control groups. Histopathological findings revealed extensive damage in the tissues of rats assigned to the negative, positive and B. ferruginea extract-treated groups. However, no damage was observed in the tissues of the standard control group. The potential efficacy and the toxicological renal effects of B. ferruginea extract-treated wastewater is discussed.

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