A study of the hepatomodulatory activity of Apium graveolens L. (celery) seed extract in rats against DEHP induced liver toxicity


G. C. Jain,* Hemant Pareek, B. S. Khajja, Kusum Jain, S. Jhalani, S. Agarwal and Sameer Sharma

In the present study, the hepatoprotective activity of methanolic extract of Apium graveolens L. (celery) seeds was tested against Di-(2- ethylhexyl) phthalate (DEHP) induced hepatotoxicity in rats. Oral administration of DEHP (1000 mg/kg b.wt/day) for 6 weeks in rats caused a significant increase in the levels of serum marker enzymes like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatases (ALP) and the levels of total bilirubin and hepatic lipid peroxidation (TBARS). The levels of serum protein, hepatic glutathione (GSH) and ascorbic acid were decreased, administration of A. graveolens seeds extract (300 mg/kg b.wt./day p.o.) for 6 weeks results in a significant recovery of these biochemical parameters toward normalcy compared with the DEPC treated and control rats.

Share this article

Awards Nomination

Select your language of interest to view the total content in your interested language

Indexed In
  • Index Copernicus
  • Google Scholar
  • Academic Keys
  • CiteFactor
  • Cosmos IF
  • Electronic Journals Library
  • Directory of Abstract Indexing for Journals
  • OCLC- WorldCat
  • Scientific Journal Impact Factor (SJIF)
  • ZB MED
  • Eurasian Scientific Journal Index
  • German cancer Research Center
  • International Institute of Organized Research
  • University of Vechta Library
  • Prerna Society of Technical Education and Research
  • Database for Statistics on Higher Education (DBH)
  • The Hamburg State University Library
  • University Library of Humboldt-Universit├Ąt zu Berlin, Germany