Demineralized bone matrix gelatin as scaffold for tissue engineering


Yong Pan, Shiwu Dong, Yong Hao, Tongwei Chu, Changqing Li, Zhengfeng Zhang and Yue Zhou*

The aim of the present study was to do a comparative light microscopical and histochemical analysis of bone regeneration processes in rabbits, with the use of demineralized bone matrix gelatin scaffolds. Our histological results showed that no gelatin scaffold was extruded, indicating that neither body fluid nor blood swept the gelatin scaffold from the implantation site, nor was the gelatin scaffold biodegraded. Additionally, no abscess or inflammation of the peripheral osseous tissues at the implantation site was observed, suggesting that the implantation of the gelatin scaffold in the vertebra bone defect did not cause histopathology or exhibit malbiocompatibility with the peripheral osseous tissues.

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