Abstract

G. Bedi*, Z. F. Tonzibo, K. R. Oussou, C. Choppard, J. P. Mahy and T. Y. Nâ??Guessan

Aqueous extracts of Chromoleana odorata are commonly used in traditional medicine as anti inflammatory drug against pains or as cataplasm to stop hemorrhage in Ivory Coast. In this work, we want to test the volatiles as essential oil extracted from the fresh leaves of C. odorata, on the cyclooxygenase function of prostaglandin-H synthase (PGHS), a protein implicated in the inflammatory process. Our goal is to make up the in vivo therapeutic activity and understand the mechanism of its biologic activity. This essential oil is extracted from leaves of C. odorata by hydrodistillation to be submitted to in vitro test. The chemical constituents of the essential oil of C. odorata increase the activity of cyclooxygenase function of PGHS with an AC 50 value of 87.5 µg/mL. Studies are in progress to indentify all the constituents implicated in the activity.