Abstract

Malik Hassan Ibrahim Mustafa, Elkhazin Ali Abd Elmageed Eltayeb, Tariq Elfatih Elmisbah, Habab Merghani Yassin Babiker, Nazar Abdelhafeez Osman Ali and Omaima Nasir

Sickle cell disease is a genetic, hereditary and chronic disease that affects the health of its carriers and might impair their health-related quality of life. The aim of the current study was to determine the sickle cell trait frequency in Sudanese patient living in Heglig area in Western of Southern Kordofan state from November 2008 to February 2009. An analytical, descriptive and cross-sectional study conducted for one hundred participants who had confirmed patient diagnosed as (Hb S disease) homozygosis patient,2-5 mL of venous blood was collected for the measurements of complete blood count, sickling test and Hb electrophoresis. Demographic data and family history were collected in a pre designed questionnaire with written consent all participants. In this study the frequency of sickle cell trait and sickle cell disease were (52%) and (14%) respectively and 34% were normal. The sickling test showed that 71 % of the study population were negative sickling test, the remaining 29 % were positive. The total erythrocytes was significantly decreased in sickle cell disease (p< 0.000) compared with normal and sickle cell trait, also the hemoglobin concentration and packed cell volume were significantly lower than that of normal individuals and sickle cell trait patients. The frequencies of sickle cell trait was higher among the participants and patients of sickle disease showed lower values of red blood cells parameters , but higher values of white blood cells and platelets compared to haemoglobin phenotype AA control participants.