Abstract

Vidoslav DekiÄ?, Niko RaduloviÄ?*, Rastko VukiÄ?eviÄ?, Biljana DekiÄ?, Zorica StojanoviÄ?-RadiÄ? and Radosav PaliÄ?

Two new and six previously known coumarin derivatives with promising biological properties were synthesized in moderate to good yields by reaction of 4-chloro-3-nitro-coumarin and the appropriate arylamine in ethyl acetate in the presence of triethylamine. The synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against pathogenic strains. A correlation between the aryl substituent identity and antimicrobial activity was discussed.