Abstract

Ming-yu Li*, Jun Wangand Zhu-ting Xu

Helicobacter pylori (H. pylori) are a bacterium implicated in the etiology of stomach cancer and ulcers. Epidemiology of the antibiotic resistance of H. pylori appears to be higher. The study was to screen an efficiency substance of Chinese herbs, which could be used in preventing and treating H. pylori diseases. A total of 40 extracted efficiency substances from Chinese herbs were examined and screened for anti-H. pylori activity performed on 96 microwell plate. 45 cases of chronic gastritis with H. pylori infected were treated by a prescription based on Chinese herbs of “clear heat and eliminate toxins”. It is showed that all except 15 extract from 40 plants were identified as having potent anti-H. pylori activities. But the most active extracts were those from Gallnut (cocoon) of Chinese Sumac (MIC: <1:512), Clover Flower Bud (MIC: 1:256), Houtuynia (MIC: 1:512), Agrimony (MIC: 1:256) Coptis Rhizome (MIC: <1:512). Subsequently, a detailed comparative study of the extract of the active herbs was performed to anti-H. pylori. Amongst the active plants the inhibitory properties of H. pylori were found prominent. Gallnut (cocoon) of Chinese Sumac, Clover Flower Bud, Houtuynia, Agrimony and Coptis Rhizome possess higher potent anti-H. pylori activity.