The immune-response enveloped-virus treatment for H22 ascitic tumors in mice


Mintao Zhong, Min Huang*, Lei Liu, Xiaoli Wang, Xingyun Li, Anhong Ning and Jing Cao

In addition to the standard therapies of chemotherapies and surgical interventions, viral therapy for tumor treatment has provided a new option for cancer patients. Whether the effects are safe, however, remains to be fully evaluated. Accordingly, we explored the immunological mechanisms of viral action against the H22 ascitic tumor, using both the Newcastle disease virus (NDV) and the parainfluenza virus (PIV). We measured IL-2 levels, NK (Natural killer) cell activity, lymphocyte proliferation rates, and the CD4+/CD8+ cell numbers' ratio. All indicators were superior in the virus-treatment group compared with the control group. Tumor cells infected by either virus induced the expression of the tumor-associated antigen, which stimulated the host immune system. 

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