Different parts of Momordica charantia and Momordica dioica are well known for their medicinal value. The present study aimed to evaluate the antidiabetic activity of crude methanolic fruit and root extracts of M. charantia and M. dioica in Alloxan induced diabetic male wistar rats. After dissecting the animal's collected liver, pancreas, and kidney, similarly studied the hepatic Notch2 gene expression in control, diabetic, and treated rats. Correspondingly we observed the glucose levels of control, diabetic, treated rats and positive control glibenclamide Momordica dioica root showed low glucose levels compared with other tested samples. In the same way, we studied, the pancreas of the Momordica charantia treated after diabetes is showing two folds up regulated Notch2 gene expression than Momordica dioica root extract. Whereas in kidney, Notch2 gene expression levels of Momordica charantia and Momordica dioica roots showed three folds up-regulated Notch2 gene expression. Momordica charantia root shows three folds Notch2 gene expression upregulated than Momordica dioica root extract. Histopathological studies also indicate severe aberration was seen in positive control and Momordica dioica fruit, but no tissue degeneration was normal in Momordica charantia fruit and root. Our findings suggest that Methanolic crude fruit and root extracts of Momordica charantia and Momordica dioica possess antidiabetic properties. Further, we can conclude that the medicinal plants Momordica charantia and Momordica dioica could be used to develop natural drugs to cure diabetes.
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