Abstract

Abdullahi Mann*, Evans C. Egwim , Barnabas Banji, Nda-Umar Abdukadir1 , Mohammed Gbate, J. T. Ekanem

The therapeutic potential of the crude extract of Dissotis rotundifolia was investigated in rats infected with Trypanosoma b. brucei. Animals were treated orally or intraperitoneally at 200, 600 and 800 mg/kg body weight. At 800 mg/kg, parasitemia was reduced by 66.7 and 78.4% after oral and intraperitoneal administration respectively. In vitro exposure of blood forms to high concentration (800 mg/kg) crude extract test resulted in complete paralysis or killing within 45 s of exposure. It is concluded that D. rotundifolia may contain antitrypanosomal constituents.