Abstract

Igor V. Ukrainets *, Igor N. Chernenok , Nikolai Yu Golik and Vera N. Kravchenko

Using the principles of creating "me-too-drugs" halogen substitution anilides of 7-hydroxy-5-oxo-2,3-dihydro1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxylic acid have been synthesized as potential diuretics. According to the results of biological trials, the substances exceeding the diuretic effect of hydrochlorothiazide in sufficiently less dose have been revealed. It has been shown that like pyrroloquinolines, which were previously studied, 7-hydroxy-5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxamides can also be the base for new highly effective diuretics and are worthy of further research.