The history of serous effusion cytology may be traced returned to the nineteenth century. Lucke and Klebs had been seemingly the primary investigators who identified the presence of malignant cells in an ascetic fluid in 1867. In 1882 Quincke changed into credited for designated descriptions of ovarian and lung most cancers cells in serous effusions. Since that point reviews on effusion cytology have begun out to seem with inside the clinical literature, and serous effusion cytology now's an ordinary diagnostic method worldwide. In latest years, with the provision of numerous commercially to be had antibodies, analysis and typing of malignant cells in serous fluids has emerge as extra dependable, obviating the time-eating and luxurious electron microscopic exam of effusion mobile blocks.
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