Abstract

Ying Shan *, Xiao-hang Ye and Hui Xin

In order to explore the mechanism of grape seed proanthocyanidin extract (GSPE) against exerciseinduced fatigue, the mice movement model was used, and the free radical and energy metabolism indicators during movement were measured. The results show that grape seed proanthocyanidin extract can improve the activity of antioxidant enzymes such as SOD and GSH- Px in the liver in exercised mice, and lower the MDA content, which may produce the effect of anti-oxidation by increasing the activity of antioxidant enzyme in the body; GSPE can keep the blood glucose in exercised mice on a stable level, increase the liver glycogen and muscle glycogen reserves, and prevent the blood glucose content, as well as the liver glycogen and muscle glycogen content, reducing after long time exercise; Meanwhile, GSPE can improve the level of TC, TG and FFA in plasma in exercised - mice, influence the fat metabolism under different conditions and promote the fat utilization. All the results above may be the anti-fatigue mechanism of GSPE.