Abstract

P. L. N Kaparthi*, Gupta Namita, Lakshmi K. Chelluri, V. Surya Prakasa Rao, P.Kantilal Shah, Adavi Vasantha, S. Kamaraju Ratnakar and K.Ravindhranath

The impact of intracoronary autologous bone marrow mononuclear cells (BMMC) in patients with DCM (dilated cardiomyopathy) with severe left ventricular (LV) dysfunction was assessed. The study included five DCM patients (age group 20 - 65 years) with ejection fraction (EF) of ≤ 30%. Mononuclear cells (Mean MNC count: 9.16 x 107 and Mean CD34 positive cell count: 3.68 x 105 ) were infused through intracoronary injection into the patients. Left ventricular ejection fraction (LVEF) was increased from 25 30% to 40 - 45% (approximately 500,000 CD34 + cells) in two of the patients. Conclusively, bone marrow mononuclear cell therapy has a potential to be considered a standard therapeutic entity for the treatment of dilated cardiomyopathy with severe LV dysfunction.