Phylogenetic and pathogenetic analysis ofM Streptococcus suis serotype 7 strain HW07 isolated from diseased pig in China

Abstract


Shujie Wang, Sen Hu, Jiamin Jin, Yonggang Liu, Gang Wang , YabinTu, Chenggang Jiang, Xuehui Cai and Xiuying Zhang

A recent isolate of Streptococcus suis serotype 7 (SS7), named HW07, was isolated from brains of pigs suspected with Streptococcus suis (S. suis) infection. The sequence types (ST) of this isolate was determined by Multilocus sequence typing (MLST) method. In order to evaluate pathogenesis of HW07 isolate, zebrafish and pigs were inoculated with HW07 strain by peritoneal cavity and vein. The results demonstrate that the 50% lethal dose (LD50) of HW07 isolate was 1.25 × 105 colony forming units (CFU)/fish and could induce pig disease, the ST number of HW07 isolate is a novel ST-ST335. Molecular and phylogenetic analysis for the recA gene of HW07 isolate showed that it joins to the I group cluster of S. suis strains, the predominant genotype in China.

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