Research on arsenic toxicity and its role

Abstract


Obinaju, Belei

Industrialization has excessively modified the discharge and distribution of arsenic in the environment through natural and anthropogenic activities. Gastrointestinal tract, Lung and Dermal absorptions account for various adverse effects associated with arsenic toxicity. The knowledge of arsenic biotransformation holds the trivalent species (DMA3+ and MMA3+) accountable for most arsenic toxicity with mechanisms of action such as the inhibition of DNA replicating or repair enzymes, interference with tissue respiration and oxidative stress. There is information of transplacental arsenic carcinogenesis and arsenic disruption of endocrine activity but most of these mechanisms remain poorly understood. More importantly, the exact dose at which arsenic induces tumours in vivo is still a major research question and therefore necessitates more scientific investigation/ research.

Share this article

Awards Nomination

Select your language of interest to view the total content in your interested language

Indexed In
  • Index Copernicus
  • Google Scholar
  • Academic Keys
  • CiteFactor
  • Cosmos IF
  • Electronic Journals Library
  • Directory of Abstract Indexing for Journals
  • OCLC- WorldCat
  • Scientific Journal Impact Factor (SJIF)
  • ZB MED
  • Eurasian Scientific Journal Index
  • German cancer Research Center
  • International Institute of Organized Research
  • University of Vechta Library
  • Prerna Society of Technical Education and Research
  • Database for Statistics on Higher Education (DBH)
  • The Hamburg State University Library
  • University Library of Humboldt-Universität zu Berlin, Germany