CBP/P300-Interacting Transactivation with Glu/Asp-rich C-terminal domain 2（CITED2), a transcriptional co-activator, severs critical roles in cell development and metabolism. Currently, CITED2 involves in fundamental cell processes via interaction with several transcription factors or cofactors, including Hypoxia-Inducible Factor 1α (HIF-1α), Transcription Factor AP 2 (TFAP2), Pitx2c, ISL1, WT1, Oct4, Smad 2/3, Peroxisome Proliferator-Activated Receptor (PPAR), Ets-1, and E2F. The latest studies have reported that CITED2 appears to have negative regulation of angiogenesis, promotive neuronal apoptosis, and inhibiting inflammation. This mini-review aims to summarize the molecular mechanisms of CITED2 and how CITED2 plays a role in angiogenesis and neuroprotection after ischemic stroke, which may provide innovative therapeutic strategies.
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