The role of CITED2 in angiogenesis and neuroprotection after ischemic stroke


Minyi Lu, Xiaoyao Yu, Jian Chen, Zhien Lan, Yangye Ou, Xiaoye Shi, Jujian Ye, Zhiqiang Xian, Peidong Zhang and Yang Guo*

CBP/P300-Interacting Transactivation with Glu/Asp-rich C-terminal domain 2(CITED2), a transcriptional co-activator, severs critical roles in cell development and metabolism. Currently, CITED2 involves in fundamental cell processes via interaction with several transcription factors or cofactors, including Hypoxia-Inducible Factor 1α (HIF-1α), Transcription Factor AP 2 (TFAP2), Pitx2c, ISL1, WT1, Oct4, Smad 2/3, Peroxisome Proliferator-Activated Receptor (PPAR), Ets-1, and E2F. The latest studies have reported that CITED2 appears to have negative regulation of angiogenesis, promotive neuronal apoptosis, and inhibiting inflammation. This mini-review aims to summarize the molecular mechanisms of CITED2 and how CITED2 plays a role in angiogenesis and neuroprotection after ischemic stroke, which may provide innovative therapeutic strategies.

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