Review on effectiveness of quercetin: A phytochemical on invasive microbes

Abstract


Noor E Azam Khan

Quercetin is a versatile natural molecule considered as flavonoid exhibiting with a variety of modes of action and broad-spectrum antibacterial effects. It may be used as an antibacterial drug because it damages bacterial cell membranes, prevents DNA breakage, and prevents bacteria from forming biofilms. It has synergistic effects with antifungal drugs because it causes disruption of cell membranes, decreases nucleic acid production, and initiates apoptosis in fungus. Quercetin's antiviral effect is attributed to its targeting of vital viral enzymes, disruption of capsid proteins, and inhibition of viral reproduction. Moreover, it has demonstrated effectiveness against a number of viral infections, including COVID-19, Ebola, Zika virus, HIV-1, HCV, etc. Through its effects on the nervous system, oxidative stress, and nematode damage, quercetin also demonstrates anthelmintic capabilities. Its potential uses range from the treatment of bacterial and fungal illnesses to the management of viral pandemics and nematode control, underscoring its adaptability and relevance in antimicrobial research.

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