Abstract

Hassan Rammal* and Rachid Soulimani

Anxiety is associated with subjective distress and many harmful physiological effects including oxidative stress, immunodepressive effect, and an increase in blood pressure. Anxiety is also implicated in a number of psychiatric disorders. The objective of this work was to study the protective property of homeopathic drugs on immunodepression caused by high anxiety level by evaluating the immunological effect of both acute and subacute intraperitoneally administration of high dilutions (9 CH, 15 CH and 30 CH) of Gelsemium sempervirens L.,  Histaminum and Poumon histamine in mice with contrasting level of anxiety evaluated in the light/dark choice test. Our results showed that these homeopathic drugs at different dilutions exert an important immunotrope effect on the cellular (granulocytes, monocytes, total lymphocytes, TCD4⁺, TCD8⁺ and NK cells) and humoral (immunoglobulins A, E and G) immunity in anxious mice.